Montpellier Non-B DNA Day
Time: 8h30-17h00 on June 9, 2022
Location: Université de Montpellier, Campus Triolet, Salle 23.01 (see map below)
We are delighted to invite you to a one-day IN-PERSON symposium on Non-B (non-canonical) DNA, ‘the blessing and the curse’ of the genome. The research over the last decade clearly demonstrated that non-B DNA forms in living cells, is ubiquitous across the tree of life, and is important for multiple molecular processes. Non-B DNA forms transiently (at 13% of the human genome, for example!) and is involved in regulation of replication, transcription, and translation.
Register here before June 2, 2022
This event is free and open to anyone. However, to better plan the symposium (e.g., to know precisely how much 
& how many 
we need) we ask you to quickly complete the registration form above. Thank you for registering!
This event is sponsored by the Montpellier Advanced Knowledge Institute on Transitions (MAK’IT) and Institut des Sciences de l’Évolution de Montpellier (ISEM)
Symposium location
Tentative program and speaker list
8:30 Coffee
Session chair: Kateryna Makova
9:00 Tutorial “What is non-B DNA?”
9:30 Keynote. Sara Richter, University of Padova, Padova, Italy. “The regulatory role of G-quadruplexes at promoters: Focus on HIV”
10:10 Marcel Méchali, Institut de Génétique Humaine (IGH), Montpellier, France) “The role of G4s in mammalian replication origins”
10:30 Coffee
Session Chair: Frédéric Brunet
11:00 Laure Dutrieux, IGH, Montpellier, France. “G4, R-loops, and mutagenesis in plasma cell cancers”
11:20 Kateryna Makova, Penn State University, University Park, USA. “Non-B DNA and evolution”
11:40 Jean-Christophe Andrau, Institut de Génétique Moléculaire de Montpellier (IGMM), Montpellier, France. “G-quadruplexes are promoter elements that function by excluding nucleosomes”
12:00 Charles Lecellier, Laboratoire d’informatique, de robotique et de microélectronique de Montpellier (LIRMM), IGMM, Montpellier, France. “Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network”
12:20 Lunch
Session chair: Sara Richter
13:20 Jose-Juan Lopez-Rubio, Laboratory of Pathogen Host Interactions (LPHI), Montpellier, France. “G4 sequences and DNA biology in malaria parasites”
13:40 Laurent Brehelin, LIRMM, Montpellier, France. “Machine learning for the identification of low complexity regions involved in Transcription Factor binding”
14:00 Cyril Esnault, IGMM, Montpellier, France. “G4-access and the role of G4s in imprinting”
14:20 Roundtable discussion “The role of non-B DNA in evolution”. Moderator: Frédéric Brunet (École Normale Supérieure de Lyon, Lyon). Participants: Nicolas Galtier (Institut des Sciences de l’Évolution de Montpellier, Montpellier), Nicolas Nègre (Diversity, Genomes and Insects-Microorganisms Interactions, Montpellier), Mark Stoneking (Laboratoire de Biométrie et Biologie Evolutive, Lyon).
14:50 Coffee
Session chair: Jose-Juan Lopez-Rubio
15:20 Stéfania Millevoi, Centre de Recherches en Cancérologie de Toulouse, Toulouse, France. “Regulation of RNA G4s impacting mitochondrial function”
15:40 Yiliang Ding, John Innes Centre, Norwich, UK. “The functional role of RNA G-quadruplex in plant growth”
16:00 Katrin Paeschke, University Hospital Bonn, Bonne, Germany. “The relevance of G4s for DNA repair after UV irradiation”
16:20 Jean-Louis Mergny, Institut Polytechnique de Paris, Palaiseau, France. “Quadruplexes are everywhere”
16:40-17:00 MAK’IT presentation
Montpellier Non-B DNA Day
Time: 8h30-17h00 on June 9, 2022
Location: Université de Montpellier, Campus Triolet, Salle 23.01 (see map below)
We are delighted to invite you to a one-day IN-PERSON symposium on Non-B (non-canonical) DNA, ‘the blessing and the curse’ of the genome. The research over the last decade clearly demonstrated that non-B DNA forms in living cells, is ubiquitous across the tree of life, and is important for multiple molecular processes. Non-B DNA forms transiently (at 13% of the human genome, for example!) and is involved in regulation of replication, transcription, and translation.
Register here before June 2, 2022
This event is free and open to anyone. However, to better plan the symposium (e.g., to know precisely how much
& how many 
we need) we ask you to quickly complete the registration form above. Thank you for registering!
Our sponsors
This event is sponsored by the Montpellier Advanced Knowledge Institute on Transitions (MAK’IT) and Institut des Sciences de l’Évolution de Montpellier (ISEM)
Symposium location
Tentative program and speaker list
8:30 Coffee
Session chair: Kateryna Makova
9:00 Tutorial “What is non-B DNA?”
9:30 Keynote. Sara Richter, University of Padova, Padova, Italy. “The regulatory role of G-quadruplexes at promoters: Focus on HIV”
10:10 Marcel Méchali, Institut de Génétique Humaine (IGH), Montpellier, France) “The role of G4s in mammalian replication origins”
10:30 Coffee
Session Chair: Frédéric Brunet
11:00 Laure Dutrieux, IGH, Montpellier, France. “G4, R-loops, and mutagenesis in plasma cell cancers”
11:20 Kateryna Makova, Penn State University, University Park, USA. “Non-B DNA and evolution”
11:40 Jean-Christophe Andrau, Institut de Génétique Moléculaire de Montpellier (IGMM), Montpellier, France. “G-quadruplexes are promoter elements that function by excluding nucleosomes”
12:00 Charles Lecellier, Laboratoire d’informatique, de robotique et de microélectronique de Montpellier (LIRMM), IGMM, Montpellier, France. “Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network”
12:20 Lunch
Session chair: Sara Richter
13:20 Jose-Juan Lopez-Rubio, Laboratory of Pathogen Host Interactions (LPHI), Montpellier, France. “G4 sequences and DNA biology in malaria parasites”
13:40 Laurent Brehelin, LIRMM, Montpellier, France. “Machine learning for the identification of low complexity regions involved in Transcription Factor binding”
14:00 Cyril Esnault, IGMM, Montpellier, France. “G4-access and the role of G4s in imprinting”
14:20 Roundtable discussion “The role of non-B DNA in evolution”. Moderator: Frédéric Brunet (École Normale Supérieure de Lyon, Lyon). Participants: Nicolas Galtier (Institut des Sciences de l’Évolution de Montpellier, Montpellier), Nicolas Nègre (Diversity, Genomes and Insects-Microorganisms Interactions, Montpellier), Mark Stoneking (Laboratoire de Biométrie et Biologie Evolutive, Lyon).
14:50 Coffee
Session chair: Jose-Juan Lopez-Rubio
15:20 Stéfania Millevoi, Centre de Recherches en Cancérologie de Toulouse, Toulouse, France. “Regulation of RNA G4s impacting mitochondrial function”
15:40 Yiliang Ding, John Innes Centre, Norwich, UK. “The functional role of RNA G-quadruplex in plant growth”
16:00 Katrin Paeschke, University Hospital Bonn, Bonne, Germany. “The relevance of G4s for DNA repair after UV irradiation”
16:20 Jean-Louis Mergny, Institut Polytechnique de Paris, Palaiseau, France. “Quadruplexes are everywhere”
16:40-17:00 MAK’IT presentation